Autocrine activation of human monocyte/macrophages by monocyte-derived microparticles and modulation by PPAR? ligands

作者：Bardelli C; Amoruso A; Canova D Federici; Fresu L G; Balbo P; Neri T; Celi A; Brunelleschi S^*

来源：British Journal of Pharmacology, 2012, 165(3): 716-728.

DOI：10.1111/j.1476-5381.2011.01593.x

• Monocyte-derived microparticles
• human monocytes
• monocyte-derived macrophages
• oxy-radical production
• inflammatory cytokines
• NF-?B
• PPAR
• rosiglitazone

BACKGROUND AND PURPOSE Microparticles (MPs), small membrane-bound particles originating from different cell types during activation or apoptosis, mediate intercellular communication, exert pro-coagulant activity and affect inflammation and other pathophysiological conditions. Monocyte-derived MPs have undergone little investigation and, to our knowledge, have never been evaluated for their possible autocrine effects. Therefore, we assessed the ability of monocyte-derived MPs to stimulate human monocytes and monocyte-derived macrophages (MDM).

• 出版日期2012-2