A single blind randomized clinical study: the efficacy of isotretinoin plus narrow band ultraviolet B in the treatment of psoriasis vulgaris

作者：Mortazavi Hossein^*; Khezri Somayeh; Hosseini Hamed; Khezri Farzaneh; Vasigh Mostafa

来源：Photodermatology Photoimmunology & Photomedicine, 2011, 27(3): 159-161.

DOI：10.1111/j.1600-0781.2011.00581.x

• isotretinoin
• narrow band ultraviolet B
• psoriasis vulgaris

In this randomized clinical trial, 39 patients with psoriasis vulgaris were randomized in two groups. Intervention group received narrow band ultraviolet B (NBUVB)+isotretinoin (0.5 mg/kg/day), control group received NBUVB+placebo. Psoriasis Area Severity Index (PASI) scoring was recorded at baseline and weeks 4, 10, and 14. Thirty-seven patients completed the study. According to recorded PASI scores the difference between efficacies of two treatments was not significant. Complete clearing was noticed in 14 and 13 patients in intervention group and controls. The mean cumulative NBUVB dose in intervention group and controls was 29.95 +/- 16.11 vs. 45.77 +/- 7.72 J/cm2 (P=0.004). Isotretinoin+NBUVB can reduce number of phototherapy sessions and cumulative NBUVB dose.

• 出版日期2011-6