A Randomized Clinical Trial of Vitamin D Supplementation in Healthy Adolescents

作者：Putman Melissa S^*; Pitts Sarah A B; Milliren Carly E; Feldman Henry A; Reinold Kristina; Gordon Catherine M

来源：Journal of Adolescent Health, 2013, 52(5): 592-598.

DOI：10.1016/j.jadohealth.2012.10.270

• Adolescent
• Bone turnover markers
• Vitamin D
• Supplementation

Purpose: The most safe and effective dose of vitamin D supplementation for healthy adolescents is currently unknown. The aim of this study was to compare the efficacy of 200 IU versus 1,000 IU of daily vitamin D-3 for supplementation in healthy adolescents with baseline vitamin D sufficiency.
Methods: We conducted a double-blind, randomized clinical trial. Fifty-six subjects, ages 11-19 years, with baseline vitamin D sufficiency received 1,000 IU or 200 IU of daily vitamin D-3 for 11 weeks. Compliance was assessed using MEMS6 Trackcaps and pill counts.
Results: Fifty-three subjects completed the clinical trial. Subjects in the two treatment arms were similar in terms of age, race, gender, body mass index, and dietary calcium and vitamin D intake. Serum 25(OH)D level in the 200 IU treatment arm was 28.1 +/- 6.2 ng/mL at baseline (mean +/- SD) and 28.9 +/- 7.0 ng/mL at follow-up. In the 1,000 IU treatment arm, 25(OH)D levels were 29.0 +/- 7.3 and 30.1 +/- 6.6 at baseline and follow-up, respectively. Mean change in 25(OH)D level did not differ significantly between treatment arms (p = .87), nor did mean change in parathyroid hormone, calcium, phosphate, bone turnover markers, fasting glucose, or fasting insulin.
Conclusions: In healthy adolescents with baseline vitamin D sufficiency, supplementation with vitamin D3 doses of 200 and 1,000 IU for 11 weeks did not increase serum 25(OH)D levels, with no significant difference observed between treatment arms.

• 出版日期2013-5