Measuring coronary artery calcification: Is serum vitamin D relevant?

作者：Malik Rehan; Aneni Ehimen C^*; Roberson Lara; Ogunmoroti Oluseye; Ali Shozab S; Shaharyar Sameer; Younus Adnan; Jamal Omar; Aziz Muhammad A; Martin Seth S; Blaha Michael J; Feldman Theodore; Agatston Arthur S; Veledar Emir; Nasir Khurram

来源：Atherosclerosis, 2014, 237(2): 734-738.

DOI：10.1016/j.atherosclerosis.2014.10.087

• Serum vitamin D
• Coronary artery calcification
• Atherosclerosis

Objectives: To synthesize evidence of the association between low vitamin D levels and subclinical coronary atherosclerosis measured by coronary artery calcium (CAC). Methods: A systematic MEDLINE search was conducted for relevant published literature. Ten studies (7 cross-sectional, 3 longitudinal) met the inclusion criteria. Results: Three of 6 studies showed association with CAC prevalence (CAC >0 or >10). Four of 8 studies found an association with CAC severity. One of two studies reported an association with CAC progression, while the only study that assessed CAC incidence did not find a significant relationship. Several of the studies had small sample sizes, many did not adjust for confounders and the cutoff for low vitamin D was inconsistent. Conclusion: There is insufficient evidence to support a consistent association between low vitamin D levels and CAC. Further high-quality studies are needed to examine serum 25-OH vitamin D in relation to subclinical coronary atherosclerosis.

• 出版日期2014-12