Association Between Insulin-Like Growth Factor Binding Protein-3 Promoter Polymorphism of-1590 C > A and Lung Cancer Susceptibility in a Chinese Han Population

作者：Dai Xiaofang; Liu Zhao; Ren Jinghua; Wu Gang^*

来源：Genetic Testing and Molecular Biomarkers, 2011, 15(5): 301-306.

DOI：10.1089/gtmb.2010.0176

Recent studies have identified a negative correlation between serum levels of insulin-like growth factor binding protein-3 (IGFBP-3) and the risk of lung cancer. In this study, polymorphisms present at the -1590 site of the IGFBP-3 promoter were evaluated in relation to lung cancer risk in a Chinese Han population. A total of 248 nonsmall cell lung cancer (NSCLC) cases and 29 small cell lung cancer cases were compared with 252 matched, healthy controls. Polymerase chain reaction-based restriction fragment length polymorphism assays were used to detect polymorphisms present. The A/A genotype and an A allele were both associated with an increased risk of NSCLC after being adjusted for age and gender (adjusted odds ratio = 2.296, 95% confidence interval = 1.133-4.655; and adjusted odds ratio 1.390, 95% confidence interval = 1.042-1.854, respectively). In conclusion, the A/A genotype and A allele of the IGFBP-3 promoter -1590 site may represent a genetic risk factor for NSCLC, with the A/A genotype being associated with a higher risk for squamous cell carcinoma than adenocarcinoma.

• 单位
  华中科技大学