Allogeneic hematopoietic stem cell transplantation following reduced-intensity conditioning for mycosis fungoides and Sezary syndrome

作者：Shiratori Souichi^*; Fujimoto Katsuya; Nishimura Machiko; Hatanaka Kanako C; Kosugi Kanaya Mizuha; Okada Kohei; Sugita Junichi; Shigematsu Akio; Hashimoto Daigo; Endo Tomoyuki; Kondo Takeshi; Abe Riichiro; Hashino Satoshi; Matsuno Yoshihiro; Shimizu Hiroshi; Teshima Takanori

来源：Hematological Oncology, 2016, 34(1): 9-16.

DOI：10.1002/hon.2162

• mycosis fungoides
• Sezary syndrome
• allogeneic hematopoietic stem cell transplantation
• reduced-intensity conditioning
• graft-versus-lymphoma effect

Advanced-stage mycosis fungoides and Sezary syndrome (MF/SS) have a poor prognosis. Allogeneic hematopoietic stem cell transplantation (HSCT), particularly using a reduced-intensity conditioning (RIC) regimen, is a promising treatment for advanced-stage MF/SS. We performed RIC-HSCT in nine patients with advanced MF/SS. With a median follow-up period of 954days after HSCT, the estimated 3-year overall survival was 85.7% (95% confidence interval, 33.4-97.9%) with no non-relapse mortality. Five patients relapsed after RIC-HSCT; however, in four patients whose relapse was detected only from the skin, persistent complete response was achieved in one patient, and the disease was manageable in other three patients by the tapering of immunosuppressants and donor lymphocyte infusion, suggesting that graft-versus-lymphoma effect and down-staging' effect from advanced stage to early stage by HSCT improve the prognosis of advanced-stage MF/SS. These results suggest that RIC-HSCT is an effective treatment for advanced MF/SS.

• 出版日期2016-3