Asymmetric Synthesis of alpha,alpha-Disubstituted alpha-Amino Acids via Enantioselective Alkylation of Azlactones under Biphasic Conditions Using P-Spiro Chiral Tetraaminophosphonium Salts as a Phase-Transfer Catalyst

作者：Uraguchi Daisuke; Asai Yoshihiro; Seto Yuki; Ooi Takashi^*

来源：Synlett, 2009, 2009(4): 658-660.

DOI：10.1055/s-0028-1087812

• aminophosphonium salt
• phase-transfer catalysis
• azlactone
• alpha,alpha-disubstituted alpha-amino acid
• asymmetric synthesis

Highly enantioselective alkylation of azlactones derived from alpha-amino acids has been achieved under solid-liquid phase-transfer conditions using P-spiro chiral tetraaminophosphonium salt as a catalyst. The resulting alkylated azlactones can be readily converted into the corresponding alpha,alpha-disubstituted alpha-amino acids through simple acidic hydrolysis.

• 出版日期2009-3-3