Toll-like receptors 2 and 4 gene polymorphisms in a southeastern Chinese population with tuberculosis

作者：Xue, Y.; Zhao, Z. Q.; Wang, H. J.; Jin, L.; Liu, C. P.; Wang, Y.; Li, J. C.^*

来源：International Journal of Immunogenetics, 2010, 37(2): 135-138.

DOI：10.1111/j.1744-313X.2009.00892.x

• SINGLE NUCLEOTIDE POLYMORPHISMS
• MYCOBACTERIUM-TUBERCULOSIS
• PULMONARY TUBERCULOSIS
• TOLL-LIKE-RECEPTOR-2 POLYMORPHISMS
• ASP299GLY VARIANT
• TLR2 MUTATION
• INFECTION
• SUSCEPTIBILITY
• DISEASE
• MICE

P>Polymorphisms of the toll-like receptor 2 (TLR2) gene (Arg677Trp, Arg753Gln) and the TLR4 gene (Asp299Gly, Thr399Ile) were investigated in 205 tuberculosis (TB) patients and 203 controls. Genetic variations were analysed by DNA sequencing. We revealed that these polymorphisms were rare in the southeastern Chinese population and were not associated with susceptibility to TB.

• 出版日期2010-4
• 单位河南大学; 浙江大学; 吉林省中医药科学院