Comparison of three S-β-CDs with different degrees of substitution for the chiral separation of 12 drugs in capillary electrophoresis

作者：Wang, Zhaokun; Zhang, Qiongwen; Luo, Linda; Sun, Tiemin^*; Guo, Xingjie^*

来源：Chirality, 2017, 29(9): 558-565.

DOI：10.1002/chir.22731

• analyte structure
• chiral selector
• degree of substitution
• enantioseparation
• sulfated beta-cyclodextrin

Three kinds of sulfated beta-cyclodextrin (S-beta-CD), including a single isomer, heptakis-6-sulfato-beta-cyclodextrin (HS-beta-CD), degree of substitution (DS) of 7, which was synthesized in our laboratory and another two commercialized randomly substituted mixtures, a sulfated beta-cyclodextrin with DS of 7 to 11, as well as a highly sulfated-beta-cyclodextrin with DS of 12 to 15, were used for the enantioresolution of 12 drugs (the beta-blockers, phenethylamines, and anticholinergic agents) in capillary electrophoresis. The enantioseparation under varying concentrations of S-beta-CD and background electrolyte pH were systematically investigated and compared. Based on the experimental results, the effect of the nature of S-beta-CD and analyte structure on the enantioseparation is discussed.

• 出版日期2017-9
• 单位沈阳药科大学