Deposition of antimicrobial coatings on microstereolithography-fabricated microneedles

作者：Gittard Shaun D; Miller Philip R; Jin Chunming; Martin Timothy N; Boehm Ryan D; Chisholm Bret J; Stafslien Shane J; Daniels Justin W; Cilz Nicholas; Monteiro Riviere Nancy A; Nasir Adnan; Narayan Roger J^*

来源：JOM, 2011, 63(6): 59-68.

DOI：10.1007/s11837-011-0093-3

Microneedles are small-scale needle-like projections that may be used for transdermal delivery of pharmacologic agents, including protein-containing and nucleic acid-containing agents. Commercial translation of polymeric microneedles would benefit from the use of facile and cost effective fabrication methods. In this study, visible light dynamic mask microstereolithography, a rapid prototyping technique that utilizes digital light projection for selective polymerization of a liquid resin, was used for fabrication of solid microneedle array structures out of an acrylate-based polymer. Pulsed laser deposition was used to deposit silver and zinc oxide coatings on the surfaces of the visible light dynamic mask microstereolithography-fabricated microneedle array structures. Agar diffusion studies were used to demonstrate the antimicrobial activity of the coated microneedle array structures. This study indicates that light-based technologies, including visible light dynamic mask microstereolithography and pulsed laser deposition, may be used to fabricate microneedles with antimicrobial properties for treatment of local skin infections.

• 出版日期2011-6