Genetics of diabetic nephropathy

作者：Carpena Mariana P; Rados Dimitris V; Sortica Denise A; de Souza Bianca M; Reis Andre Fernandes; Canani Luis Henrique; Crispim Daisy^*

来源：Arquivos Brasileiros de Endocrinologia e Metabologia, 2010, 54(3): 253-261.

DOI：10.1590/S0004-27302010000300002

• Nephropathy
• diabetes mellitus
• genetics
• genetic predisposition

The increasing prevalence of diabetes mellitus has led to a growing number of chronic complications including diabetic nephropathy (DN). In addition to its high prevalence, DN is associated with high morbidity and mortality especially due to cardiovascular diseases. It is well established that genetic factors play a role in the pathogenesis of DN and genetically susceptible individuals can develop it after being exposed to environmental factors. DN is probably a complex, polygenic disease. Two main strategies have been used to identify genes associated to DN: analysis of candidate genes, and more recently genome-wide scan. Great efforts have been made to identify these main genes, but results are still inconsistent with different genes associated to a small effect in specific populations. The identification of the main genes would allow the detection of those individuals at high risk for DN and better understanding of its pathophysiology as well. Arq Bras Endocrinol Metab, 2010;54(3):253-61

• 出版日期2010-4