Axicon lens-based cone shell configuration for depth-sensitive fluorescence measurements in turbid media

作者：Ong Yi Hong; Liu Quan^*

来源：Optics Letters, 2013, 38(15): 2647-2649.

DOI：10.1364/OL.38.002647

We have developed a novel noncontact setup to implement a cone shell illumination and detection configuration using axicon lenses for depth-sensitive fluorescence measurements. The setup was demonstrated experimentally to be capable of detecting fluorescence from a two-layered turbid agar phantom with a larger sensitivity to the deep layer and a larger range of sensitivity to either layer than a conventional cone configuration implemented by a microscope objective lens. Furthermore, the axicon lens-based setup eliminates the need of moving the objective lens up or down to achieve depth-sensitive measurements, which effectively improves the consistency of optical coupling and thus would be preferred in a clinical setting.

• 出版日期2013-8-1
• 单位南阳理工学院