Antiviral Furanosesquiterpenes from Commiphora erythraea

作者：Cenci Elio; Messina Federica; Rossi Elisabetta; Epifano Francesco; Marcotullio Maria Carla^*

来源：Natural Product Communications, 2012, 7(2): 143-144.

• Commiphora erythraea (Burseraceae)
• Furanodienone
• Myrrhone
• Parainfluenza type 3 virus
• HEp-2 cells
• Antiviral activity

The crude methanolic extract obtained from C. erythraea resin was chromatographed on silica gel with solvent of increasing polarity. The extract and fractions were evaluated for cytotoxicity and antiviral activity [parainfluenza type 3 virus (PIV3)] by plaque forming units (PFU) reduction assay using HEp-2 cells (human larynx epidermoid carcinoma cell line). From the active fraction, five compounds were isolated and tested. Only two of these showed anti-PIV3 activity with a selectivity index (SI) of 66.6 and 17.5, respectively. Both the compounds are furanosesquiterpenoids.

• 出版日期2012-2