Hydroxyapatite-alendronate composite systems for biocompatible materials

作者：Neamtu Johny; Bubulica Maria Viorica^*; Rotaru Andrei; Ducu Catalin; Balosache Oana Elena; Manda Valentin Costel; Turcu Stiolica Adina; Nicolicescu Claudiu; Melinte Razvan; Popescu Mariana; Croitoru Octavian

来源：Journal of Thermal Analysis and Calorimetry, 2017, 127(2): 1567-1582.

DOI：10.1007/s10973-016-5905-9

• Ceramics
• Microporous materials
• Chemical synthesis
• Thermogravimetric analysis
• X-ray diffraction

In this study, hydroxyapatite-alendronate composites were synthesized from calcium nitrate, diammonium hydrogen phosphate and alendronate by chemical precipitation method. The obtained materials were analysed by physical-chemical methods, while the compositional and structural characteristics of hydroxyapatite-alendronate phases were determined by a combination of crystallographic, spectroscopic and thermal analysis investigations; moreover, the alendronate content, its maximal incorporation efficiency to hydroxyapatite and stability were determined. A two-level full factorial design was chosen to determine the optimum set of process parameters (synthesis temperature, reactant addition rate and ripening time) and their effects on various hydroxyapatite-alendronate characteristics: alendronate incorporation efficiency, hydroxyapatite crystallite size (XRD), hydroxyapatite particle size distribution (DLS). These effects were quantified using design of experiments. The in vitro release profile of alendronate from hydroxyapatite-alendronate tablets was assessed.

• 出版日期2017-2