Higher Incidence of Hypospadias in Monochorionic Twins

作者：Visser Remco; Burger Nienke C M; van Zwet Erik W; Hilhorst Hofstee Yvonne; Haak Monique C; van den Hoek Joop; Oepkes Dick; Lopriore Enrico^*

来源：Twin Research and Human Genetics, 2015, 18(5): 591-594.

DOI：10.1017/thg.2015.55

• hypospadia
• twins
• monochorionic
• dichorionic
• fetal growth restriction

Background: Hypospadias is associated with twinning. The incidence of hypospadias in monochorionic and dichorionic male twins is, however, yet to be determined. Methods: All medical records of monochorionic and dichorionic twins admitted to our neonatal nursery between January 2004 and August 2013 were reviewed for the presence of hypospadias. Results: A total of 350 monochorionic and 303 dichorionic male twins were included in the study. The incidence of hypospadias in monochorionic and dichorionic groups was 4% (14/350) and 1% (3/303) (p = .016) respectively. In 11 of the 15 twin couples, hypospadias occurred in the twin with the lowest birth weight. The rate of hypospadias in twin infants small-for-gestational-age group was 10% (6/60) compared with 2% (11/593) in the appropriate-for-gestational-age group (p = .002). In a multivariate analysis, both monochorionicity and small-for-gestational-age were independently associated with hypospadias, odds ratio 4.1 (95% confidence interval (CI): 1.1-14.7) and 6.1 (95% CI: 2.2-17.2) respectively. Conclusions: The incidence of hypospadias is four-fold higher in monochorionic twins compared with dichorionic twins. Hypospadias is also independently associated with small-for-gestationalage.

• 出版日期2015-10