Differential Functionalization of 1,6-Naphthyridin-2(1H)-ones through Sequential One-Pot Suzuki-Miyaura Cross-Couplings

作者：Montoir David; Tonnerre Alain; Duflos Muriel; Bazin Marc Antoine^*

来源：European Journal of Organic Chemistry, 2014, 2014(7): 1487-1495.

DOI：10.1002/ejoc.201301631

• Synthetic methods
• C-C coupling
• Cross-coupling
• Nitrogen heterocycles
• Palladium
• Microwave chemistry

A practical synthesis of 7-chloro-3-iodo-1-methyl-1,6-naphthyridin-2(1H)-one is described that starts from 2-chloro-4-(methylamino)nicotinaldehyde. The dihalo compound then undergoes sequential, site-selective Suzuki-Miyaura cross-coupling reactions to afford highly functionalized 1,6-naphthyridones in good yields.

• 出版日期2014-3