Antimicrobial, antioxidant and cytotoxic activities of propolis from Melipona orbignyi (Hymenoptera, Apidae)

作者：Campos Jaqueline Ferreira; dos Santos Uilson Pereira; Benitez Macorini Luis Fernando; Mestriner Felipe de Melo Adriana Mary; Perrella Balestieri Jose Benedito; Paredes Gamero Edgar Julian; Lima Cardoso Claudia Andrea; Souza Kely de Picoli; dos Santos Edson Lucas

来源：Food and Chemical Toxicology, 2014, 65: 374-380.

DOI：10.1016/j.fct.2014.01.008

• Stingless bee
• Oxidative stress
• Hemolysis
• Lipid peroxidation
• Necrosis
• Anti-tumor activity

Propolis from stingless bees is well known for its biologic properties; however, few studies have demonstrated these effects. Therefore, this study aimed to investigate the chemical composition and antimicrobial, antioxidant and cytotoxic activities of propolis from the stingless bee Melipona orbignyi, found in Mato Grosso do Sul, Brazil. The chemical composition of the ethanol extract of propolis (EEP) indicated the presence of aromatic acids, phenolic compounds, alcohols, terpenes and sugars. The EEP was active against the bacterium Staphylococcus aureus and the fungus Candida albicans. The EEP showed antioxidant activity by scavenging free radicals and inhibiting hemolysis and lipid peroxidation in human erythrocytes incubated with an oxidizing agent. Additionally, EEP promoted cytotoxic activity and primarily necrotic death in K562 erythroleukemia cells. Taken together, these results indicate that propolis from M. orbignyi has therapeutic potential for the treatment and/or prevention of diseases related to microorganism activity, oxidative stress and tumor cell proliferation.

• 出版日期2014-3