Neonatal outcomes following extensive cardiopulmonary resuscitation in the delivery room for infants born at less than 33 weeks gestational age

作者：Soraisham Amuchou Singh^*; Lodha Abhay Kumar; Singhal Nalini; Aziz Khalid; Yang Junmin; Lee Shoo K; Shah Prakesh S; Network Canadian Neonatal

来源：Resuscitation, 2014, 85(2): 238-243.

DOI：10.1016/j.resuscitation.2013.10.016

• Adrenaline
• Cardiopulmonary resuscitation
• Epinephrine
• Neonatal outcome
• Premature

Aim: To examine the neonatal mortality and morbidity of infants born at <33 weeks gestational age (GA) who received extensive delivery room cardiopulmonary resuscitation (DR-CPR) immediately after birth.
Design/methods: In this retrospective cohort study, we performed secondary analyses of data from infants born at <33 weeks GA and admitted to participating NICUs in the Canadian Neonatal Network between January 2010 and December 2011. Infants were divided into two groups based on birth weight (<1000 g and >= 1000 g) and neonatal morbidity and mortality compared using bivariate and multivariate analyses.
Results: Of the 8033 eligible infants, 419 (5.2%) received DR-CPR. For infants weighing <1000 g at birth, 10.9% (outborn: 21.6%, inborn: 7.6%) received DR-CPR, whereas 3.4% (outborn: 9.6%, inborn: 2.2%) of those weighing >= 1000 g received DR-CPR. If infants received DR-CPR there was increased risk of mortality, bronchopulmonary dysplasia (BPD) and severe brain injury. Logistic regression analysis showed DR-CPR was associated with increased mortality (adjusted odds ratio [aOR]: 2.09, 95% CI [1.39, 3.14]) in infants born weighing <1000 g. Among infants born weighing >= 1000 g, DR-CPR was associated with increased mortality (aOR: 7.16, 95% CI [3.88, 13.2]), severe brain injury (aOR: 3.08, 95% CI [1.82, 5.22]), BPD (aOR: 2.14, 95% CI [1.25, 3.65]), pneumothorax (aOR: 3.11, 95% CI [1.53, 6.31]) and intestinal perforation (aOR: 3.47, 95% CI [1.46, 8.24]).
Conclusions: DR-CPR is associated with increased risk of mortality and morbidity especially in preterm infants born weighing >= 1000 g. Long-term neurodevelopmental follow up is warranted for these infants.

• 出版日期2014-2