摘要

Skeleton extracting plays an important role in many fields, including medical image processing, bioinformatics, pattern recognition and others, and the research of inherent topological structure of object shapes is therefore needed. Most existing approaches, applied on the coronary artery images, face the problems of low accuracy, high computation cost and lack of radius information. In this paper, a novel skeleton extracting method for 3D coronary artery is proposed. The proposed method is capable of extracting skeleton robustly and automatically by employing a new medialness measuring function, level-set graph and multiple-hypothesis tracking strategy. It also involves a pre-segmentation step for the goal of reducing undetermined image noise disturbance. The proposed skeleton extracting method is consistent and scalable for vessels of different sizes, and has been validated on both synthetic and clinical images. Experimental results show that the proposed method outperforms most existing algorithms.