Asymmetric synthesis of beta-dialkylamino alcohols by transfer hydrogenation of alpha-dialkylamino ketones

作者：Kosmalski Tomasz; Wojtczak Andrzej; Zaidlewicz Marek^*

来源：Tetrahedron: Asymmetry , 2009, 20(10): 1138-1143.

DOI：10.1016/j.tetasy.2009.03.014

Transfer hydrogenation of representative aryl and heteroaryl dialkylaminomethyl ketones with formic acid-triethylamine, catalyzed by RuCl[(R,R)-TsDPEN](eta-p-cymene), produces the corresponding beta-dialkylamino alcohols, 97-99% ee, in 50-73% yields. Asymmetric synthesis of (R)-macromerine, 98% ee, the cactus Coryphantha macromeris alkaloid, is also described.

• 出版日期2009-6-5