A novel therapeutic target for peripheral nerve injury-related diseases: aminoacyl-tRNA synthetases

作者：Park Byung Sun; Yeo Seung Geun; Jung Junyang^*; Jeong Na Young

来源：Neural Regeneration Research, 2015, 10(10): 1656-1662.

DOI：10.4103/1673-5374.167766

• nerve regeneration
• aminoacyl-tRNA synthetases
• dorsal horn
• peripheral nerve injury
• in situ hybridization
• neural regeneration

Aminoacyl-tRNA synthetases (AminoARSs) are essential,enzymes that perform the first step of protein synthesis. Beyond their original roles, AminoARSs possess non-canonical functions, such as cell cycle regulation and signal transduction. Therefore, AminoARSs represent a powerful pharmaceutical target if their non-canonical functions can be controlled. Using AminoARSs-specific primers, we screened mRNA expression in the spinal cord dorsal horn of rats with peripheral nerve injury created by sciatic nerve axotomy. Of 20 AminoARSs, we found that phenylalanyl-tRNA synthetase beta chain (FARSB), isoleucyl-tRNA synthetase (TARS) and methionyl-tRNA synthetase (MARS) mRNA expression was increased in spinal dorsal horn neurons on the injured side, but not in glial cells. These findings suggest the possibility that FARSB, JARS and MARS, as a neurotransmitter, may transfer abnormal sensory signals after peripheral nerve damage and become a new target for drug treatment.

• 出版日期2015-10