Duodenal application of Li plus in a submaximal therapeutic dose inhibits exocrine pancreatic secretion and modulates gastro-duodenal myoelectrical activity in a conscious pig model

作者：Naughton Violetta^*; Hedemann Mette S; Naughton Patrick J; McSorley Emeir; Laerke Helle N

来源：Canadian Journal of Physiology and Pharmacology, 2013, 91(9): 764-772.

DOI：10.1139/cjpp-2012-0396

• MMC
• migrating motor complex
• pancreatic juice
• lithium therapy
• side effects

This study tested whether duodenal application of lithium inhibits gastroduodenal motility, and whether it suppresses secretion from the exocrine pancreas. Five suckling pigs, 16-18 days old, were surgically fitted with 3 serosal electrodes on the wall of the gastric antrum and the duodenum for electromyography of smooth muscles, and with a pancreatic duct catheter and a duodenal T-cannula for collection and re-entrant flow of pancreatic juice. After the recovery period, on alternative days, each animal was tested once with an intraduodenal infusion of Li+ (100 mmol.L-1 C3H5LiO3, 10 mL.kg(-1).h(-1)) for 1 h, and once with an intraduodenal infusion of NaCl (154 mM, 10 ml.kg(-1).h(-1)), also for 1 h, with the first treatment, i.e., Li+ or NaCl, randomly assigned. Individual pigs served as their own controls, with data recorded prior to a treatment being used as the baseline. Li+ increased the duration of quiescence (P %26lt; 0.05) and activity phase (P %26lt; 0.05) in the antrum, thus increasing (P %26lt; 0.05) the duration of antral myoelectrical cycles. Li+ shortened (P %26lt; 0.05) phase I, but it did not affect phase II or phase III or the MMC in the duodenum. Li+ inhibited pancreatic juice outflow as well as pancreatic enzyme and bicarbonate output (P %26lt; 0.05 for all pancreatic parameters).

• 出版日期2013-9