Association between aspirin use and the prevalence of nonalcoholic fatty liver disease: a cross-sectional study from the Third National Health and Nutrition Examination Survey

作者：Shen H^*; Shahzad G; Jawairia M; Bostick R M; Mustacchia P

来源：Alimentary Pharmacology and Therapeutics, 2014, 40(9): 1066-1073.

DOI：10.1111/apt.12944

BackgroundMany basic mechanistic studies found that aspirin inhibited multiple pathways involved in non-alcoholic fatty liver disease (NAFLD) development.
AimTo investigate an association between aspirin use and NAFLD prevalence in the general US population.
MethodsWe conducted a cross-sectional analysis of data from the Third National Health and Nutrition Examination Survey (NHANES III). We included 11416 adults aged 20-74years who underwent ultrasonography; of those, 2889 were identified as having NAFLD and 8527 as controls. Aspirin use during the month prior to interview was categorised as never use (0 times), occasional use (1-14 times) and regular use (15 times).
ResultsIn the multivariate unconditional logistic regression analysis, regular relative to no aspirin use was inversely associated with prevalent NAFLD [odds ratio (OR)=0.62, 95% confidence interval (CI) 0.51-0.74; P for trend=0.04], a finding that was primarily limited to men (OR=0.32, 95% CI 0.23-0.45; P for interaction<0.01) and those who were older (>60years) (OR=0.21, 95% CI 0.14-0.30; P for interaction<0.01).
ConclusionThese findings, from the first human study to investigate an association of aspirin use with NAFLD, suggest that regular aspirin use (15times per month) may be associated with a lower prevalence of NAFLD, primarily among men and older patients.

• 出版日期2014-11