Anti-inflammatory Constituents from the Aerial Parts of Iris minutiaurea

作者：Woo Kyeong Wan; Lee Ki Ho; Jang Ji Hun; Kim Min Suk; Cho Hyun Woo; Cho Jung Hee; An Byeongkwan

来源：Natural Product Communications, 2016, 11(6): 817-819.

DOI：10.1177/1934578x1601100630

<jats:p> Phytochemical investigation of the methanol extract of the aerial parts of Iris minutiaurea (Iridaceae) using column chromatography led to the isolation of a new xanthone glycoside, 1-hydroxy-3,5-dimethoxy-xanthone-6- O-β-D-glucoside (1), together with one known flavonoid glycoside (2). The structure of this new compound was elucidated by analysis of spectroscopic, including ID (<jats:sup>1</jats:sup>H, <jats:sup>13</jats:sup>C), 2D NMR (COSY, HMQC, HMBC), and high resolution fast atom bombardment mass spectrometric (HR-FAB-MS) data and enzyme hydrolysis. We found that compounds 1 and 2 significantly suppressed production of NO, and pro-inflammatory cytokine in LPS-induced RAW264.7 cells. These results suggest that compound 1 and 2 have anti-inflammatory activity related with production of TNF-α, IL-6, IL-β, and NO in macrophages, and then compound 1 were more efficient than compound 2 in lowering the level of proinflammatory cytokine. </jats:p>

• 出版日期2016-6