A novel Bcl-XL inhibitor Z36 that induces autophagic cell death in Hela cells

作者：Lin, Jian; Zheng, Zhibin; Li, Yanjun; Yu, Wenyu; Zhong, Wu; Tian, Songhai; Zhao, Fang; Ren, Xiaobai; Xiao, Junhai; Wang, Nan; Liu, Siyang; Wang, Lili; Sheng, Fugeng; Chen, Yingyu; Jin, Changwen; Li, Song; Xia, Bin^*

来源：Autophagy, 2009, 5(3): 314-320.

DOI：10.4161/auto.5.3.7888

• autophagy
• autophagic cell death
• NMR
• Bcl-X-L
• Bcl-2
• inhibitor

Inhibition of Bcl2 family proteins Bcl-X-L and Bcl-2 represents a promising drug development strategy for cancer treatment by triggering apoptosis in cancer cells. Here we report a novel Bcl-X-L inhibitor, Z36, which unexpectedly induces only autophagic cell death, but not apoptosis. This special property distinguishes Z36 from other previously reported Bd-X-L and Bcl-2 inhibitors that induce cancer cell death mainly through apoptosis, and makes Z36 an attractive molecular tool for studying the cellular regulation of autophagic cell death and apoptosis.

• 出版日期2009-4-1
• 单位北京大学; 中国人民解放军军事医学科学院