Diastereoselective synthesis of novel heterocyclic scaffolds through tandem Petasis 3-component/intramolecular Diels-Alder and ROM-RCM reactions

作者：Ishoey Mette; Petersen Rico G; Petersen Michael A; Wu Peng; Clausen Mads H; Nielsen Thomas E

来源：Chemical communications, 2017, 53(68): 9410-9413.

DOI：10.1039/c7cc02948a

A high-yielding, stereoselective and extraordinarily complexity-generating Petasis 3-component/intramolecular Diels-Alder reaction has been developed. In combination with ROM-RCM, rapid access to complex sp(3)-rich heterocyclic scaffolds amenable to subsequent functionalization and library synthesis is provided.

• 出版日期2017-9-4