Ubiquitin-like proteins and their roles in archaea

作者：Maupin Furlow Julie A^*

来源：Trends in Microbiology, 2013, 21(1): 31-38.

DOI：10.1016/j.tim.2012.09.006

• protein modification
• sulfur carrier
• molybdenum
• tRNA
• proteasomes

This review highlights the finding that ubiquitin-like (Ubl) proteins of archaea (termed SAMPs) function not only as sulfur carriers but also as protein modifiers. UbaA (an El ubiquitin-activating enzyme homolog of archaea) is required for the SAMPs to be covalently attached to proteins. The SAMPs and UbaA are also needed to form sulfur-containing biomolecules (e.g., thiolated tRNA and molybdenum cofactor). These findings provide a new perspective on how Ubl proteins can serve as both sulfur carriers and protein modifiers in the absence of canonical E2 ubiquitin conjugating or E3 ubiquitin ligase enzyme homologs.

• 出版日期2013-1