Antiepileptic Drug Therapy: An Update Review

作者：Steinhoff B J^*

来源：Klinische Neurophysiologie, 2012, 43(2): 131-137.

DOI：10.1055/s-0032-1309055

• epilepsy
• anticonvulsants
• serum concentration
• recommendations

The adminstration of drugs is still the standard therapy for epilepsies. In the majority of patients, satisfying seizure control without intolerable adverse effects is achieved. As a consequence of new antiepileptic drugs therapeutic possibilities have improved. However, different labellings, varying pharmacological profiles, generics and apparently a lack of long-term data on tolerability sometimes make it difficult to decide and understand which strategy is best. This update review summarises the current standards and comments on the first drug choice, the strategy if the first therapy fails, the phenomenon of drug resistance, and special aspects such as the concept of so-called rational antiepileptic drug therapy, the appropriate use of generics and during pregnancy, respectively.

• 出版日期2012-6