科研之友
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摘要
Using the Hg2+-induced desulfurization reaction of thiosemicarbazide derivative, we designed and synthesized a novel "turn on" coumarin-based fluorescent probe L with a simple structure for detecting mercury ion (II). Spectroscopy revealed that the probe responds selectively to mercury ions over other metal ions with marked fluorescence enhancement. Detection of Hg2+ was effective at pH 7.0-9.5, with high selectivity and significant effect in HeLa cells, human umbilical vein endothelial cells and Escherichia coli, but no cytotoxicity. This probe could be an ideal and practical Hg2+ probe with important biological significance.
- 出版日期2014-1-7
- 单位山东大学
