Antifungal activity of a novel quercetin derivative bearing a trifluoromethyl group on Candida albicans

作者：Tempesti Tomas C; Gabriela Alvarez M; de Araujo Marcelo Francisco; Aragao Catunda Junior Francisco Eduardo; de Carvalho Mario Geraldo; Durantini Edgardo N^*

来源：Medicinal Chemistry Research, 2012, 21(9): 2217-2222.

DOI：10.1007/s00044-011-9750-x

• Antifungal activity
• Flavonoid
• Rutin
• Quercetin
• Candida albicans

In this study, a novel quercetin derivative bearing a trifluoromethyl group was synthesized by the nucleophilic aromatic substitution reaction between rutin and 2-chloro-5-(trifluoromethyl)-1,3-dinitrobenzene in basic medium. This synthetic quercetin showed antifungal activity against Candida albicans cultures. The results indicated a remarkable increase in the biological activity of this compound as compared to rutin.

• 出版日期2012-9