Asynchrony of spectral blue-shifts of quantum dot based digital homogeneous immunoassay

作者：Liu, Xiaojun; Huang, Conghui; Dong, Xiuling; Liang, Aiye; Zhang, Yusu; Zhang, Qingquan; Wang, Qi^*; Gai, Hongwei^*

来源：Chemical communications, 2018, 54(93): 13103-13106.

DOI：10.1039/c8cc06754f

• CROSS-CORRELATION SPECTROSCOPY
• RESONANCE ENERGY-TRANSFER
• MULTIPLEXED DETECTION
• PROTEIN-DETECTION
• FLUORESCENCE
• MICROSCOPY
• ASSAY

A femtomolar digital homogenous immunoassay is developed based on sensitively distinguishing the immunocomplexes labeled with quantum dot (QD) aggregates from the excessive free monodisperse single QDs. The success in quantifying the carcino-embryonic antigen and alpha-fetoprotein in plasma validated the feasibility of our approach for clinical tests.

• 出版日期2018-12-4
• 单位大连医科大学