A genome-wide association meta-analysis identifies new childhood obesity loci

作者：Bradfield Jonathan P; Taal H Rob; Timpson Nicholas J; Scherag Andre; Lecoeur Cecile; Warrington Nicole M; Hypponen Elina; Holst Claus; Valcarcel Beatriz; Thiering Elisabeth; Salem Rany M; Schumacher Fredrick R; Cousminer Diana L; Sleiman Patrick M A; Zhao Jianhua; Berkowitz Robert I; Vimaleswaran Karani S; Jarick Ivonne; Pennell Craig E; Evans David M; St Pourcain Beate; Berry Diane J; Mook Kanamori Dennis O; Hofman Albert; Rivadeneira Fernando

来源：Nature Genetics, 2012, 44(5): 526-+.

DOI：10.1038/ng.2247

Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (%26gt;= 95th percentile of body mass index (BMI)) and 8,318 controls (%26lt;50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P %26lt; 5 x 10(-6) in nine independent data sets (2,818 cases and 4,083 controls), we observed two loci that yielded genome-wide significant combined P values near OLFM4 at 13q14 (rs9568856; P = 1.82 x 10(-9); odds ratio (OR) = 1.22) and within HOXB5 at 17q21 (rs9299; P = 3.54 x 10(-9); OR = 1.14). Both loci continued to show association when two extreme childhood obesity cohorts were included (2,214 cases and 2,674 controls). These two loci also yielded directionally consistent associations in a previous metaanalysis of adult BMI1.

• 出版日期2012-5
• 单位河北医科大学