Size distribution of salbutamol/ipratropium aerosols produced by different nebulizers in the absence and presence of heat and humidification

作者：Yang Ssu Han; Yang Tsung Ming; Lin Hui Ling; Tsai Ying Huang; Fang Tien Pei; Wan Gwo Hwa^*

来源：Pulmonary Pharmacology & Therapeutics, 2018, 48: 22-27.

DOI：10.1016/j.pupt.2017.10.009

• Lung model
• Ventilator
• Bronchodilator
• Vibrating mesh nebulizer
• Small volume nebulizer

Background: Few studies have evaluated the size distribution of inhaled and exhaled aerosolized drugs, or the effect of heated humidification on particle size and lung deposition. The present study evaluated these aspects of bronchodilator (salbutamol/ipratropium) delivery using a lung model in the absence and presence of heat and humidification.
Methods: We positioned filters to collect and measure the initial drug, inhaled drug, and exhaled drug. Particle size distribution was evaluated using an 8-stage Marple personal cascade impactor with 0.2-mu m polycarbonate filters.
Results: A greater inhaled drug mass was delivered using a vibrating mesh nebulizer (VMN) than by using a small volume nebulizer (SVN), when heated humidifiers were not employed. When heated and humidified medical gas was used, there was no significant difference between the inhaled drug mass delivered by the VMN and that delivered by the SVN. A significantly greater mass of inhaled 1.55-mu m drug particles was produced by the VMN than with the SVN, under heated and humidified conditions. However, the mass median aerodynamic diameters (MMADs) of the aerosolized drug produced by the SVN and VMN did not differ significantly under the same conditions.
Conclusions: The VMN produced more fine particles of salbutamol/ipratropium, and the drug particle size clearly increased in the presence of heat and humidification.

• 出版日期2018-2
• 单位长春大学