A Convenient Synthesis of N,N-Dimethylformamidines from Sulfonamides

作者:Chen Yantao*; Graden Henrik; Aurell Carl Johan; Gibson James
来源:Synthesis (Germany), 2015, 47(10): 1405-1412.
DOI:10.1055/s-0034-1380277

摘要

N,N-Dimethylformamidines were synthesized from sulfonamides using the Vilsmeier reagent as a cleavage activator. The reactions were performed under mild conditions achieving good to excellent yields. The chemistry presented can also be used as a deprotection strategy when amines or anilines are protected with sulfonyl groups, such as the tosyl group.

  • 出版日期2015-5