Application of a sensitive nanocomposite-based electrochemical sensor for voltammetric determination of dicyclomine hydrochloride in real samples

作者：Madrakian Tayyebeh^*; Maleki Somayeh; Afkhami Abbas

来源：Journal of the Iranian Chemical Society, 2016, 13(10): 1819-1825.

DOI：10.1007/s13738-016-0899-6

• Gold nanoparticles
• Multiwalled carbon nanotubes
• Dicyclomine hydrochloride
• Differential pulse voltammetry
• Electrochemical sensor

In the present study a glassy carbon electrode, modified with nanocomposite of gold nanoparticles/multiwalled carbon nanotubes (GNPs/MWCNTs/GCE), was used for determination of dicyclomine hydrochloride (DcCl). The results showed that synergetic effects of GNPs and MWCNTs highly improved electrochemical response and sensitivity of the sensor. The electrochemical oxidation of DcCl was investigated by cyclic voltammetry and differential pulse voltammetry. Also, scanning electron microscopy and energy dispersive x-ray spectroscopy were used to evaluate microstructure of electrochemical sensor. The effect of various experimental parameters including pH and scan rate on the voltammetric response of DcCl were investigated. Under the optimal conditions linear response was observed in range of 1.0-1.2 x 10(2) A mu mol L-1 for DcCl. The lower detection limit was found to be 0.40 A mu mol L-1 for DcCl. The investigated method showed good stability, reproducibility and repeatability. The proposed sensor was successfully applied to the determination of DcCl in real samples.

• 出版日期2016-10