Genetic polymorphism for IFN gamma+874T/A in patients with acute toxoplasmosis

作者：Neves Elizabeth de Souza^*; Land Curi Andre Luis; de Albuquerque Maira Cavalcanti; Palhano Silva Cassius Schnel; da Silva Laura Berriel; Bueno Wendy Fernandes; dos Reis Amendoeira Maria Regina; Bonecini Almeida Maria da Gloria; Fernandes Octavio

来源：Revista da Sociedade Brasileira de Medicina Tropical, 2012, 45(6): 757-760.

• Toxoplasmosis
• Interferon gamma
• Retinochoroiditis

Introduction: A single nucleotide polymorphism (SNP) in the gene encoding gamma interferon influences its production and is associated with severity of infectious diseases. This study aimed to evaluate the association of IFN gamma+874T/A SNP with duration of disease, morbidity, and development of retinochoroiditis in acute toxoplasmosis. Methods: A case-control study was conducted among 30 patients and 90 controls. Results: Although statistical associations were not confirmed, A-allele was more common among retinochoroiditis cases and prolonged illness, while T-allele was more frequent in severe disease. Conclusions: Despite few cases, the results could indicate a relation between IFN gamma+874T/A single nucleotide polymorphism and clinical manifestations of toxoplasmosis.

• 出版日期2012-12