Allogeneic Stem-Cell Transplantation in Patients With NPM1-Mutated Acute Myeloid Leukemia: Results From a Prospective Donor Versus No-Donor Analysis of Patients After Upfront HLA Typing Within the SAL-AML 2003 Trial

作者：Roellig Christoph; Bornhaeuser Martin; Kramer Michael; Thiede Christian; Ho Anthony D; Kraemer Alwin; Schaefer Eckart Kerstin; Wandt Hannes; Haenel Mathias; Einsele Hermann; Aulitzky Walter E; Schmitz Norbert; Berdel Wolfgang E; Stelljes Matthias; Mueller Tidow Carsten; Krug Utz; Platzbecker Uwe; Wermke Martin; Baldus Claudia D; Krause Stefan W; Stoelzel Friedrich; von Bonin Malte; Schaich Markus; Serve Hubert; Schetelig Johannes; Ehninger Gerhard

来源：Journal of Clinical Oncology, 2015, 33(5): 403-410.

DOI：10.1200/JCO.2013.54.4973

Purpose The presence of a mutated nucleophosmin-1 gene (NPM1(mut)) in acute myeloid leukemia (AML) is associated with a favorable prognosis. To assess the predictive value with regard to allogeneic stem-cell transplantation (SCT), we compared the clinical course of patients with NPM1(mut) AML eligible for allogeneic SCT in a donor versus no-donor analysis.
Patients and Methods Of 1,179 patients with AML (age 18 to 60 years) treated in the Study Alliance Leukemia AML 2003 trial, we identified all NPM1(mut) patients with an intermediate-risk karyotype. According to the trial protocol, patients were intended to receive an allogeneic SCT if an HLA-identical sibling donor was available. Patients with no available donor received consolidation or autologous SCT. We compared relapse-free survival (RFS) and overall survival (OS) depending on the availability of a suitable donor.
Results Of 304 eligible patients, 77 patients had a sibling donor and 227 had no available matched family donor. The 3-year RFS rates in the donor and no-donor groups were 71% and 47%, respectively (P = .005); OS rates were 70% and 60%, respectively (P = .114). In patients with normal karyotype and no FLT3 internal tandem duplication (n = 148), the 3-year RFS rates in the donor and no-donor groups were 83% and 53%, respectively (P = .004); and the 3-year OS rates were 81% and 75%, respectively (P = .300).
Conclusion Allogeneic SCT led to a significantly prolonged RFS in patients with NPM1(mut) AML. The absence of a statistically significant difference in OS is most likely a result of the fact that NPM1(mut) patients who experienced relapse responded well to salvage treatment. Allogeneic SCT in first remission has potent antileukemic efficacy and is a valuable treatment option in patients with NPM1(mut) AML with a sibling donor.

• 出版日期2015-2-10