Achromobacter species in cystic fibrosis: Cross-infection caused by indirect patient-to-patient contact

作者：Hansen C R^*; Pressler T; Ridderberg W; Johansen H K; Skov M

来源：Journal of Cystic Fibrosis, 2013, 12(6): 609-615.

DOI：10.1016/j.jcf.2013.05.004

• Cross-infection
• Achromobacter xylosoxidans
• Pulmonary infection

Background and methods: Achromobacter species leads to chronic infection in an increasing number of CF patients. We report 2 cases of Achromobacter ruhlandii cross-infection between patients after well-described indirect contact. %26lt;br%26gt;Results: Both cases were young, stable, CF patients without chronic infections and with normal FEV1, but experienced clinical deterioration after visits to the home of a CF patient with A. ruhlandii infection and after sharing facilities with an A. ruhlandii infected CF patient on a skiing vacation, respectively. Both cases became positive for A. ruhlandii in airway secretions and were colonized with A. ruhlandii in their sinuses. %26lt;br%26gt;Aggressive, long-term antibiotic treatment led to clinical stability. One of the cases developed chronic A. ruhlandii infection. %26lt;br%26gt;Conclusion: A. species can cause cross-infection even after a short period of indirect contact between infected and non-infected CF patients. Patients should be followed closely for several months before the possibility of cross-infection is ruled out.

• 出版日期2013-12