Antibody Responses to Norovirus Genogroup GI.1 and GII.4 Proteases in Volunteers Administered Norwalk Virus

作者：Ajami Nadim J; Barry Meagan A; Carrillo Berenice; Muhaxhiri Zana; Neill Frederick H; Prasad B V Venkataram; Opekun Antone R; Gilger Mark A; Graham David Y; Atmar Robert L; Estes Mary K^*

来源：Clinical and Vaccine Immunology, 2012, 19(12): 1980-1983.

DOI：10.1128/CVI.00411-12

An assay was developed to detect antibodies against two norovirus proteases among participants in a Norwalk virus (GI.1) challenge study. Prechallenge seroprevalence was lower against the protease from the homologous GI.1 virus than against protease from a heterologous GII.4 strain. Seroresponses were detected for 14 of 19 (74%) infected persons.

• 出版日期2012-12