Alleviation of collagen-induced arthritis by Plumbago zeylanica in mice

作者：Poosarla Aparanji^*; Kumar B Veerendra; Rao T Raghava; Rao D N; Athota Rama Rao

来源：Pharmaceutical Biology, 2007, 45(1): 54-59.

DOI：10.1080/13880200601028271

• anti-arthritic
• collagen-induced arthritis
• immunomodulatory
• Plumbago zeylanica
• rheumatoid arthritis
• T-cell proliferation

The current study investigates the role of an ethyl acetate fraction of the root extract of Plumbago zeylanica L. (Plumbaginaceae) (PZE-6) in its antiarthritic activity in collagen type II-induced arthritis in DBA/1 mice and in the suppression of humoral antibody and stimulation of T cell mediated responses. PZE-6 suppressed collagen type II-induced arthritis in DBA/1 mice in a dose-dependent manner. In this experimental model, PZE-6 could suppress the total IgG and IgG2a anti-collagen antibody responses significantly as evidenced by ELISA. The MIC was found to be 0.1 mg/mouse. In addition, the treatment with PZE-6 stimulated Con A-induced T-cell proliferation to normal levels in arthritic mice.

• 出版日期2007-1
• 单位河北医科大学