科研之友
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摘要
Solid support-enabled site isolation has previously allowed to use paraldehyde as an acetaldehyde surrogate in aldol reactions. However, only electron-poor aldehydes were tolerated by the system. Herein, we show that the temporary conversion of benzaldehyde into eta(6)-benzaldehyde Cr(CO)(3) circumvents this limitation. Asymmetric synthesis of (R)-Phenoperidine, as well as formal syntheses of (R)Fluoxetine and (R)-Atomoxetine, illustrate the benefits of this strategy.
- 出版日期2018-7-19
