Non-tumour bone marrow lymphocytes correlate with improved overall survival in childhood acute lymphoblastic leukaemia

作者：Edwin Claire; Dean Joanne; Bonnett Laura; Phillips Kate; Keenan Russell^*

来源：Pediatric Blood and Cancer, 2016, 63(10): 1848-1851.

DOI：10.1002/pbc.26093

• acute lymphoblastic leukaemia
• immunophenotype
• lymphocyte
• overall survival
• paediatric cancer

Composition of tumour immune cell infiltrates correlates with response to treatment and overall survival (OS) in several cancer settings. We retrospectively examined immune cells present in diagnostic bone marrow aspirates from paediatric patients with B-cell acute lymphoblastic leukaemia. Our analysis identified a sub-group (approximate to 30% of patients) with >2.37% CD20 and >6.05% CD7 expression, which had 100% OS, and a sub-group (approximate to 30% of patients) with 2.37% CD20 and 6.05% CD7 expression at increased risk of treatment failure (66.7% OS, P < 0.05). Immune cell infiltrate at diagnosis may predict treatment response and could provide a means to enhance immediate treatment risk stratification.

• 出版日期2016-10