Novel therapeutic option for orbital atypical lymphoid hyperplasia

作者：Talaulikar Dipti^*; Tridgell David; Leong David; Dahlstrom Jane E; Cherian Maya; Prosser Ian; Sunderland Ken

来源：Clinical and Experimental Ophthalmology, 2010, 38(9): 892-894.

DOI：10.1111/j.1442-9071.2010.02378.x

• B-lymphocyte
• haematopathology
• lymphoproliferative disorder
• orbital
• pathology of lymphoid lesion

P>Ocular lymphoid tumours represent a spectrum of lymphoproliferative disease and can be subdivided into benign or reactive lymphoid hyperplasia, indeterminate or atypical lymphoid proliferations and malignant lymphoma. Treatment options include a wait and watch approach, systemic steroids, local radiotherapy or systemic chemotherapy. We describe a case of bilateral atypical lymphoid hyperplasia treated successfully with combination immunotherapy and radiotherapy. A 60-year-old lady presented with proptosis and left supra-orbital mass and was diagnosed to have bilateral atypical lymphoid hyperplasia. She had extensive extraocular facial infiltrates but no other sites of involvement on staging investigations. She was treated with eight doses of rituximab 375 mg/m2 at weekly intervals with a good partial response, followed by consolidative radiotherapy. Rituximab may be an effective treatment adjunct/alternative for patients with atypical lymphoid hyperplasia of the orbit, particularly where widespread lesions preclude the use of initial radiotherapy.

• 出版日期2010-12