A Facile Access to Some New Pyrazole, 1,3,4-Thiadiazole, and Thiophene Derivatives via -Ketosulfones

作者：Dawood Kamal M^*; Kheder Nabila A; Ragab Eman A; Mohamed Sanaa N

来源：Phosphorus, Sulfur, and Silicon and the Related Elements, 2010, 185(2): 330-339.

DOI：10.1080/10426500902796980

• Hydrazonoyl halides
• ketosulfones
• pyrazoles
• pyridines
• 1
• 3
• 4-thiadiazoles
• thiophenes

3-Bromoacetyl-1,5-diphenyl-1H-pyrazole-4-carbonitrile (1) reacts with sodium benzenesulfinate to give the corresponding ketosulfone 2. Treatment of 2 with hydrazonoyl chlorides 3a,b gives the 3,3'-bipyrazoles 5a,b. Ketosulfone 2 reacts also with arylidenemalononitriles to give the pyrazolylpyridones 10a,b. The reaction of compound 2 with phenylisothiocyanate and potassium hydroxide and treating intermediate with hydrazonoyl halides and with -haloketones gives the 1,3,4-thiadiazoles 18a-c and thiophenes 21a-f, respectively.

• 出版日期2010