Nano bioresearch approach by microtechnology

作者：Collard Dominique^*; Kim Soo Hyeon; Osaki Toshihisa; Kumemura Momoko; Kim Beomjoon; Fourmy Dominique; Fujii Teruo; Takeuchi Shoji; Karsten Stanislav L; Fujita Hiroyuki

来源：Drug Discovery Today, 2013, 18(11-12): 552-559.

DOI：10.1016/j.drudis.2013.02.002

To progress in basic science and drug development, convenient methodology for detecting specific biological molecules and their interaction in living organism is in high demand. After more than 20 years of increasing research efforts, micro and nanotechnologies are now mature to propose a new class of miniature devices and principles enabling compartmentalized bioassays. Among them, this review proposes various examples that include array of electro-active microwells for highly parallel single cell analysis, cost-effective nanofluidic for DNA separation, parallel enzymatic reaction in 100 pL droplet and high-throughput platform for membrane proteins assays. The micro devices are presented with relevant experiments to foresee their future contribution to translational research and drug discovery.

• 出版日期2013-6