In vitro inhibitory potential of methanolic extract of Celosia argentea var. cristata on tyrosinase, acetylcholinesterase and butyrylcholinesterase enzymes

作者：Saqib Fatima; Janbaz Khalid Hussain; Sherwani Maryam Khan

来源：Bangladesh Journal of Pharmacology, 2015, 10(2): 449-454.

DOI：10.3329/bjp.v10i2.22880

<jats:p>&lt;p&gt;In the current study, methanol extract of &lt;em&gt;Celosia argentea&lt;/em&gt; var. &lt;em&gt;cristata&lt;/em&gt; was tested for its inhibitory potential against tyrosinase, acetylcholinesterase and butyrylcholinesterase enzymes at the concentration of 0.5 mM by ELISA microtiter plate assays. A significant tyrosinase inhibitory activity (63.6%), acetylcholinesterase inhibitory activity (80.3%) and butyrylcholinesterse inhibitory activity (68.24%) was shown by crude methanolic extract of &lt;em&gt;C. argentea&lt;/em&gt; var. &lt;em&gt;cristata&lt;/em&gt; with respective IC&lt;sub&gt;50 &lt;/sub&gt;values of 268.5 ± 0.2 µg/mL, 73.6 ± 0.1 µg/mL and 132.8 ± 0.9 µg/mL. The result of this study reveals the use of &lt;em&gt;C. argentea&lt;/em&gt; var. &lt;em&gt;cristata&lt;/em&gt; in skin hyperpigmentation, Parkinson’s disease and neurodegenerative disorders like Alzheimer’s disease and dementia.&lt;/p&gt;</jats:p>

• 出版日期2015