科研之友
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摘要
Purpose: To evaluate the long-term corneal safety of topical mitomycin C (MMC) used during photorefractive keratectomy to prevent haze formation in highly myopic eyes. Methods: Twenty-eight patients with bilateral high myopia underwent photorefractive keratectomy. One eye was randomly assigned to intraoperative 0.02% MMC and the fellow eye to conventional treatment. Each eye was checked at baseline and at 5 years after surgery using in vivo corneal confocal microscopy. Results: At baseline, the endothelial cell density was 2970 +/- 295 cells per square millimeter in the MMC-treated eyes and 2839 +/- 323 cells per square millimeter in the control eyes. At 5 years, it was 2803 +/- 307 and 2780 +/- 264 cells per square millimeter, respectively (P = 0.27). The number of corneal nerve fibers was 3.9 +/- 1.6 in the MMC-treated eyes and 4.4 +/- 1.3 in the control eyes. At 5 years, it was 3.0 +/- 1.6 and 2.7 +/- 1.3, respectively (P = 0.15). The density of corneal nerves was 9600 +/- 2915 mu m/mm(2) in the MMC-treated eyes and 11,352 +/- 3898 mu m/mm(2) in the control eyes. At 5 years, the density was higher in the MMC-treated eyes (6790 +/- 2447 mu m/mm(2)) than in the control eyes (6024 +/- 2977 mu m/mm(2)) (P = 0.003). The number of nerve beadings at baseline was 12.9 +/- 1.7/100 mu m in the MMC-treated eyes and 12.3 +/- 2.0/100 mu m in the control eyes. At 5 years, it was 9.9 +/- 2.6/100 and 9.4 +/- 2.9/100 mu m, respectively (P = 1.00). At 5 years, corneal nerve branching and tortuosity were similar in the 2 groups (P = 0.88 and 0.54, respectively). Epithelium thickness remained statistically unchanged (P = 0.69). Conclusions: Intraoperative use of topical 0.02% MMC compared with standard treatment does not induce significant long-term corneal changes, as assessed by in vivo corneal confocal microscopy.
- 出版日期2011-6
