A20 Controls Macrophage to Elicit Potent Cytotoxic CD4(+) T Cell Response

作者：Wang Lifeng; Hong Bangxing; Jiang Xiaoxia; Jones Lindsey; Chen Si Yi; Huang Xue F^*

来源：PLos One, 2012, 7(11): e48930.

DOI：10.1371/journal.pone.0048930

Emerging evidence indicates that CD4(+) T cells possess cytotoxic potential for tumor eradication and perforin/granzyme-mediated cytotoxicity functions as one of the important mechanisms for CD4(+) T cell-triggered cell killing. However, the critical issue is how the cytotoxic CD4(+) T cells are developed. During the course of our work that aims at promoting immunostimulation of APCs by inhibition of negative regulators, we found that A20-silenced M drastically induced granzyme B expression in CD4(+) T cells. As a consequence, the granzyme-highly expressing CD4(+) T cells exhibited a strong cytotoxic activity that restricted tumor development. We found that A20-silenced M Phi activated cytotoxic CD4(+) T cells by MHC class-II restricted mechanism and the activation was largely dependent on enhanced production of IFN-gamma.

• 出版日期2012-11-7