Associations of depression with impaired glucose regulation, newly diagnosed diabetes and previously diagnosed diabetes in Chinese adults

作者：Sun, J. C.; Xu, M.; Lu, J. L.; Bi, Y. F.; Mu, Y. M.; Zhao, J. J.; Liu, C.; Chen, L. L.; Shi, L. X.; Li, Q.; Yang, T.; Yan, L.; Wan, Q.; Wu, S. L.; Liu, Y.; Wang, G. X.; Luo, Z. J.; Tang, X. L.; Chen, G.; Huo, Y. N.; Gao, Z. N.; Su, Q.; Ye, Z.; Wang, Y. M.; Qin, G. J.; Deng, H. C.; Yu, X. F.; Shen, F. X.; Chen, L.; Zhao, L. B.; Wang, T. G.; Lai, S. H.; Li, D. H.; Wang, W. Q.; Ning, G.^*

来源：Diabetic Medicine, 2015, 32(7): 935-943.

DOI：10.1111/dme.12649

• LONGITUDINAL REACTION
• RISK-EVALUATION
• TYPE-2
• MELLITUS
• INDIVIDUALS
• METAANALYSIS
• PREVALENCE
• SYMPTOMS
• PREDICTORS
• ANXIETY

Aim To examine the association between depression and impaired glucose regulation, newly diagnosed diabetes and previously diagnosed diabetes in middle-aged and elderly Chinese people, and whether depression was associated with different treatment regimens or durations of diabetes.
Methods A cross-sectional study was performed among 229 047 adults living in the community aged 40 years from 25 centres in China. The self-reported depression rating scale Patient Health Questionnaire 9 (PHQ-9) was used to diagnose probable and sub-threshold depression. Glucose metabolism status was determined according to World Health Organization 1999 diagnostic criteria.
Results The numbers of participants with normal glucose regulation, impaired glucose regulation, newly diagnosed diabetes and previously diagnosed diabetes were 120 458, 59 512, 24 826 and 24 251, respectively. The prevalence of subthreshold depression in the total sample of participants was 4.8% (4.8%, 4.8%, 4.4% and 5.6% from normal glucose regulation to previously diagnosed diabetes, respectively), and the prevalence of probable depression was 1.1% (1.1%, 1.0%, 0.9% and 1.8% from normal glucose regulation to previously diagnosed diabetes, respectively). Compared with participants with normal glucose regulation, those with previously diagnosed diabetes had increased odds of probable depression [odds ratio (OR) = 1.61, 95% confidence interval (CI) 1.39-1.87] and sub-threshold depression (OR = 1.14, 95% CI 1.06-1.24), after adjustment for multiple confounding factors. Newly diagnosed diabetes or impaired glucose regulation was not associated with depression. Among those with previously diagnosed diabetes, insulin treatment was associated with greater odds of depression compared with no treatment or oral anti-diabetic medicine.
Conclusion Previously diagnosed diabetes, but not newly diagnosed diabetes or impaired glucose regulation, was associated with a higher prevalence of depression. Patients receiving insulin were more likely to have depression than those not receiving treatment or being treated with oral anti-diabetic medicine.

• 出版日期2015-7
• 单位山东大学; 南京医科大学; 大连市中心医院; 广西医科大学; 重庆医科大学; 上海交通大学; 温州医科大学; 贵州医科大学; 江西省人民医院; 安徽医科大学; 西南医科大学; 山东省立医院; 兰州大学; 中国科学院上海生命科学研究院; 华中科技大学; 吉林大学; 中国人民解放军总医院; 浙江省疾病预防控制中心; 福建省立医院; 上海市闵行区中心医院; 福建医科大学; 中山大学; 哈尔滨医科大学; 郑州大学