科研之友
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摘要
Many studies have indicated possible associations between a polymorphism of adiponectin receptor 1 (ADIPOR1) rs1342387 and risk of cancer, but contradictory results have been reported. The main aim of this study was to draw a reliable conclusion about the relationship between the rs1342387 polymorphism and cancer incidence, by conducting a literature search of Pubmed, Embase, Wanfang and Cochrane libraries. Eleven studies including 3, 738 cases and 4, 748 controls were identified in this meta-analysis. The ADIPOR1 rs1342387 polymorphism was associated with risk of colorectal cancer for all genetic comparison models (GG vs AA, OR: 1.44, 95% CI: 1.21 - 1.70; G carriers vs A carriers, OR: 1.23, 95% CI: 1.11 - 1.36; dominant model, OR: 1.28, 95% CI: 1.10 - 1.49 and recessive model, OR: 1.31, 95% CI: 1.12 - 1.55). Stratified by ethnicity, the rs1342387 polymorphism was significantly associated with risk of colorectal cancer in Asian ancestry for all genetic comparison models (GG vs AA, OR: 1.56, 95% CI: 1.26- 1.92; G carriers vs. A carriers OR: 1.30, 95% CI: 1.18 - 1.43; dominant model OR: 1.31, 95% CI: 1.08 - 1.60 and recessive model OR: 1.44, 95% CI: 1.26 - 1.64), but not in Caucasian or mixed (Caucasian mainly) groups. In summary, the ADIPOR1 rs1342387 polymorphism is significantly associated with risk of colorectal cancer among individuals of Asian ancestry.
